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A peaceful woman The medical point of view |
After having made sure that her kidney function was normal |
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| October 1993 | ||
| Evaluation of calcium metabolism | ||
| - Calcium level - Phosphorus levels - 25 OH D3 |
2,11 mmol/l 1,60 mmol/l 22,7 ng/ml |
(low) (normal) (normal) |
| Evaluation of the parathyroid function | ||
| - PTH 1-84 | 10,5 pg/ml | (low) |
| Evaluation of the bone metabolism | ||
| - Alkaline phosphatase | 50 UI/l | (normal) |
| March 1994 | ||
| Evaluation of calcium metabolism | ||
| - Calcium level - Phosphorus levels |
2,15 mmol/l 1,62 mmol/l |
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| Evaluation of the bone metabolism | ||
| - Alkaline phosphatase | 51 UI/l | |
Saint Antoine Hospital (Lunar ®)
Densitometry of the unfractured right hip
1992: Substitute hormonal treatment
1993: Graft of natural coral in the left hip
| 1990 | 2000 | 2003 | |||||
| DMO (g/cm²) | DMO (g/cm²) | T-Score | Z-Score | DMO (g/cm²) | T-Score | Z-Score | |
| NECK | 0,653 | 0,740 | -2,00 | -0,011 | 0,750 | -1,90 | +0,50 |
| TROCH | 0,554 | 0,552 | -2,16 | -0,87 | 0,510 | -2,50 | -0,80 |
| INTER | |||||||
| WARD | 0,603 | 0,654 | -1,97 | +0,40 | 0,582 | -2,50 | +0,40 |
BIOLOGICAL CONSTANTS
Here are the results of the exams performed on October 5 th , 2006 at the LCL Laboratory in Paris
| After having verified that her kidney function was normal | |
| I° - Evaluation of calcium metabolism | |
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Normal calcium levels: 91 mg/l - Ionized calcium - the active fraction - normal: 50,80 mg/l - Phosphorus levels: 37 mg/l - Intact PTH: 43 pg/ml - 25 OH Vitamin D : 23 ng/ml |
(VR : 86 - 103 mg/l ) (VR : 46,40 - 52,40 mg/l) (VR : 25 to 49 mg/l) (VR : 15 to 65 pg/ml) (Optimal concentration: 20 to 50 ng/ml) |
| II° - Evaluation of the bone metabolism: bone markers | |
| Markers of bone mineralization: - Osteocalcin: 25 ng/ml |
(VR : 10 to 23 ng/ml) |
| Markers of bone resorption: - CTX - Crosslaps : telopeptide C terminal of Type I collagen - PIN1- N terminal propeptide of Type I procollagen |
0,46 ng/ml 49 µg/l |
 Reference values of osteocalcin for subjects who have a physiological bone mineralization:- Woman: 10 to 23 ng/ml Reference values of the useful ratio of PTH - intact PTH- Woman: 15 to 65 pg/ml Reference values of serum CrossLaps rates in adult subjects with physiological bone- Woman: 0,10 à 0,32 ng/ml Reference values of PIN1 in adult women with physiological bone resorption- Woman: 15 à 60 µg/ml |
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BONE DENSITOMETRY
Mrs. H.J. 78 y.o.
03-10-2006
| BD (g/cm²) Right Hip | BD (g/cm²) Left Hip | ||
| Neck | 0,600 g/cm² | Neck | 0,515 g/cm² |
| Troch | 0,484 g/cm² | Troch | 0,508 g/cm² |
| Inter | 0,995 g/cm² | Inter | 0,911 g/cm² |
| Ward | 0,416 g/cm² | Ward | 0,360 g/cm² |
| Total | 0,800 g/cm² | Total | 0,764 g/cm² |
| (Dr Jean Charles RUIZ) | |||
We note that the left femur which was broken twice, operated on multiple times (twice near the hip and four times near the knee) has a total mineral bone density that is lower by 0.036 g/cm 2 ± 2% than the other femur - in other words a has a level of mineralization that is not very different from that of the unbroken femur.
BONE DENSITOMETRY
T-Score and Z-Score
| Right Hip | Left Hip | |||
| T-Score | Z-Score | T-Score | Z-Score | |
| Neck | -2,5 | -0,3 | -3,4 | -0,6 |
| Ward | -3,2 | -0,3 | -3,8 | -0,2 |
| Total | -2,0 | -0,2 | -2,3 | -0,2 |
We note that while Mrs. H.J., in spite of the two fractures of the same femur, a fracture of the wrist and a fracture of a rib, has a near-normal level of mineralization for a person her age in both the healthy femur (right) and the fractured femur (left).
EVOLUTION of the BD
(mg/cm²) from 1989 to 2006
| 1992: Substitute hormonal treatment | 1993: graft of natural coral in the left femur |
We note a regularly increasing mineralization since 1989 at the level of the neck of the femur, a quasi stable mineralization at the level of the greater trochanter. On the other hand, we note a regular decrease at the level of the Ward triangle. Neither of the two hips has received natural coral.
BIOLOGICAL BONE MARKERS
october 2006
| OSTEOCALCIN: result technically verified from the same sample CTX-CROSSLAPS: C terminal telopeptide of type I collagen PIN1: N terminal propeptide of type I procollagen |
Women: VR : 10 to 23 ng/ml Women: VR : 0,10 to 0,32 ng/ml Women: VR : 15 to 60 µg/l |
Mrs. H.J has physiological bone resorption and bone mineralization that is above average.
THOUGHTS
Assessment 14 years after the natural coral graft
In the course of the first 18 months of the Substitute Hormonal Treatment
- Three fractures occurred.
Since the coral graft + Substitute Hormonal Treatment
- No fracture has occurred.
- The densitometry of the neck of the femur has increased (it has gone from 0,600 g/cm² to 0,750 g/cm²).
- The calcium level has normalized.
- Bone resorption is physiological.
- Bone remineralization is above average.
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